Searchable abstracts of presentations at key conferences in endocrinology

ea0096p15 | Section | UKINETS2023

Alternative splicing and its role in the pathology of Pancreatic and Small Intestine Neuroendocrine tumours

Garan Jones Dr , Trinidad Moreno-Montilla Ms. Maria , Bamford Dr. Rosie , Hodgetts Dr. Harry , Jefferies Dr. Aaron , Martins Dr. Maria , Ibanez Costa Dr. Alejandro , Afi Leslie Dr. Kaiyven , Richardson Dr. Sarah , Capdevila Dr. Jaume , Jon Mill Professor , Lorna Harries Professor , Krista Rombouts Professor , Justo Castano Professor , Thirlwell Professor Chrissie

Neuroendocrine tumours, although considered a rare neoplasia, have been increasing in incidence in developed countries over the last few decades. Previous research has identified several genetic components1. Despite this there is a gap in our knowledge of the causal mechanisms underlying the development of these tumours, with a low background mutation rate and lack of putative variants suggesting that other mechanisms are responsible. Recent work in Pancreatic Neuro...